header_dots_v04
idea #22

Endotoxins’ effect
on dairy cattle performance

 

A topic of increasing interest and importance for dairy cattle production are the effects of endotoxins on livestock performance parameters. It is becoming more and more evident that endotoxins play a role in the incidence of infectious and metabolic diseases in dairy cattle, risking: health, performance, and profit.

The rumen, an endotoxin’s home

Due to the richness in gram-negative and gram-positive bacterial species in the rumen, endotoxins are abundant in the gastrointestinal tract of cattle. Endotoxins, a structural component of the outer membrane of gram-negative bacteria, are mainly released when bacteria are lysed. After being lysed, endotoxins can enter the bloodstream where they stimulate the immune system and trigger immune responses. During infectious diseases caused by bacteria, endotoxins significantly contribute to symptoms and pathology.

Stress, an opening to the body

High-producing dairy cattle are sensitive to stressful situations, which puts their system under a lot of pressure, especially during the transition period. These circumstances raise the risk of toxins passing the gut wall and entering the bloodstream, increasing pressure on the cow’s health. As well as local intestinal inflammation, once beyond the gut wall, endotoxins can also be present at other sites of the body, such as the mammary gland and uterus.

Binding, the solution

Understanding the connection between endotoxins and dairy cattle disease holds significant potential for developing preventative solutions. Different means of control, aimed at the reduction of bacterial contamination, have been tested with varying results. Within Agrimprove, we think a cost-effective method would be the dual benefit of our toxin binders to capture endotoxins and mycotoxins in the gastrointestinal tract and prevent them from entering the systemic circulation. First indications seen by our experts prove our solution lowers the number of endotoxins present in an in vitro rumen environment. Studies are underway to validate their impact on in vivo live animals.

Instead of focusing on reducing gram-positive bacteria, one could focus on reducing the pathogenic gram-negative bacteria observed to proceed E. cecorum problems.

Solutions worth considering

Ready for improvement? Try one of our suggested solutions with a proven added value.

VITANOX

The natural antioxidant for swine, poultry and ruminants

Details

Your Agrimprove expert

Do you have a question or want personalized advice? Your Agrimprove expert is willing to help. Reach out directly or request to be contacted at your convenience.

Jannemieke Gieling – van Avezaath
Category Manager Cattle
Contact request

Stay up-to-date

Would you like to be kept informed of our latest developments? Register here and stay up to date.

I'm interested in(Required)
Consent(Required)
This field is for validation purposes and should be left unchanged.